Motif ID: SOX{8,9,10}.p2

Z-value: 1.580


Transcription factors associated with SOX{8,9,10}.p2:

Gene SymbolEntrez IDGene Name
SOX10 6663 SRY (sex determining region Y)-box 10
SOX8 30812 SRY (sex determining region Y)-box 8
SOX9 6662 SRY (sex determining region Y)-box 9

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SOX9chr17_+_67628772-0.391.4e-01Click!
SOX10chr22_-_367098140.263.2e-01Click!
SOX8chr16_+_9720640.107.0e-01Click!


Activity profile for motif SOX{8,9,10}.p2.

activity profile for motif SOX{8,9,10}.p2


Sorted Z-values histogram for motif SOX{8,9,10}.p2

Sorted Z-values for motif SOX{8,9,10}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of SOX{8,9,10}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_+_52665196 1.828 NM_017409
HOXC10
homeobox C10
chr9_+_123501186 1.725 DAB2IP
DAB2 interacting protein
chr7_+_2638156 1.661 TTYH3
tweety homolog 3 (Drosophila)
chr2_+_232281491 1.639 PTMA
prothymosin, alpha
chr20_-_38751289 1.587 NM_005461
MAFB
v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian)
chr3_-_11598829 1.583 NM_001128220
VGLL4
vestigial like 4 (Drosophila)
chr12_-_120725210 1.494 LOC338799
hypothetical LOC338799
chr3_-_187309442 1.481 NM_004454
ETV5
ets variant 5
chr2_+_232281470 1.420 NM_001099285
NM_002823
PTMA

prothymosin, alpha

chr1_-_32574185 1.363 NM_023009
MARCKSL1
MARCKS-like 1
chr11_+_20005704 1.355 NAV2
neuron navigator 2
chr9_+_115303527 1.314 NM_130795
RGS3
regulator of G-protein signaling 3
chr1_+_43539239 1.278 NM_005424
TIE1
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
chr7_-_27171673 1.248 NM_152739
HOXA9
homeobox A9
chr17_+_75366524 1.232 NM_005189
NM_032647
CBX2

chromobox homolog 2

chr7_+_2638108 1.213 NM_025250
TTYH3
tweety homolog 3 (Drosophila)
chr1_-_2451543 1.200 NM_001010926
HES5
hairy and enhancer of split 5 (Drosophila)
chr6_+_30796064 1.175 TUBB
tubulin, beta
chr1_+_158636987 1.171 NM_020335
VANGL2
vang-like 2 (van gogh, Drosophila)
chr6_+_43565192 1.149 NM_001146017
TJAP1
tight junction associated protein 1 (peripheral)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 37 entries
enrichment   p-value GO term description
2.25 6.53e-05 GO:0030036 actin cytoskeleton organization
2.21 1.46e-05 GO:0030029 actin filament-based process
1.85 2.55e-03 GO:0007264 small GTPase mediated signal transduction
1.65 4.48e-02 GO:0007010 cytoskeleton organization
1.62 3.25e-04 GO:0051128 regulation of cellular component organization
1.55 3.36e-02 GO:0030182 neuron differentiation
1.52 8.66e-03 GO:0048699 generation of neurons
1.50 1.16e-02 GO:0022008 neurogenesis
1.47 7.97e-05 GO:0007399 nervous system development
1.46 7.00e-05 GO:0009653 anatomical structure morphogenesis
1.46 9.89e-03 GO:0022607 cellular component assembly
1.45 2.50e-07 GO:0048869 cellular developmental process
1.45 4.21e-07 GO:0030154 cell differentiation
1.43 1.82e-04 GO:0006996 organelle organization
1.38 5.81e-09 GO:0048856 anatomical structure development
1.38 1.25e-07 GO:0048731 system development
1.35 2.54e-08 GO:0007275 multicellular organismal development
1.35 1.82e-05 GO:0071842 cellular component organization at cellular level
1.34 2.07e-09 GO:0032502 developmental process
1.33 1.05e-03 GO:0051252 regulation of RNA metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
1.94 2.65e-02 GO:0005911 cell-cell junction
1.21 2.22e-06 GO:0005634 nucleus
1.09 1.61e-04 GO:0044424 intracellular part
1.08 3.77e-04 GO:0005622 intracellular
1.08 4.80e-02 GO:0043226 organelle

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.26 3.93e-02 GO:0030674 protein binding, bridging
2.20 4.72e-02 GO:0060090 binding, bridging
1.77 1.72e-02 GO:0003779 actin binding
1.76 6.47e-05 GO:0008092 cytoskeletal protein binding
1.61 1.70e-06 GO:0001071 nucleic acid binding transcription factor activity
1.61 1.70e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.55 2.29e-03 GO:0019899 enzyme binding
1.50 4.70e-04 GO:0030528 transcription regulator activity
1.30 1.07e-03 GO:0003677 DNA binding
1.13 1.37e-03 GO:0005515 protein binding
1.07 1.07e-02 GO:0005488 binding